ea0063p533 | Diabetes, Obesity and Metabolism 2 | ECE2019
Jeon Jae-Han
, Lee In-Kyu
, Choi Yeon-Kyung
, Park Keun-Gyu
, Kim Na-Young
, Park Sung Don
, Ahn Jin Hee
, Kim Min-Ji
Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. We report here a new series of allosteric PDK4 inhibitor modified from hit anthraquinone. A novel PDK4 inhibitor, namely compound 8c, improved glucose tolerance in diet-induced obese mice. PDH activity in muscle and liver was enhance d by compound 8c treatment. Given the importance of PDK4 in immune cells including mast cel...